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CAR-T cell Therapy in India

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Why Would Someone Need to Have CAR T-cell Therapy?

A person who is experiencing a relapse of lymphoma or leukemia and other types of blood cancer can opt for this therapy. The therapy is best for blood cancers, while the research for treating other cancers is currently underway.

Thus, in case the other treatment options have been unsuccessful or you have faced relapse of a blood cancer type, this can be the answer.

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Overview

India is quickly becoming the benchmark for availing advanced therapies such as CAR-T cell therapy and is one of the top destinations to avail world-class treatment at relatively lower costs. Think 60% lower rates than countries such as the US, Turkey, Thailand, and similar others.

The following section looks at the different conditions that CAR-T therapy treats.

Conditions That CAR T Cell Can Treat Include

  • B-cell acute lymphoblastic leukemia (ALL)

  • Diffuse large B-cell lymphoma (DLBCL)

  • Multiple myeloma

  • Mantle cell lymphoma

  • Primary mediastinal large B-cell lymphoma

Requirements & Procedure: CAR T Cell Therapy

Here are the requirements and procedure of CAR-T therapy:

Requirements

A suitable candidate for CAR-T cell therapy is someone who matches the following criteria:

  1. Type of cancer - There’s only a small percentage of cancers that CAR-T therapy can take care of - one of those is blood cancers. CAR-T cell therapy is unsuitable for solid tumors.

  2. Treatment history - Patients usually need to have previously failed or relapsed standard treatments for CAR-T cell therapy consideration.

  3. Patient health - Overall health of the person should be relatively good to withstand the rigorous CAR-T cell therapy.

  4. Support system - You must have a caregiver during the T-cell extraction and for the first month post-infusion. In addition, the patient and the support must stay close to the treatment center for some time after the infusion.

  5. Clinical trials - The eligibility criteria to participate in clinical trials vary depending on the trial and its protocol. In addition, some trial protocols require you to have a caregiver.

Procedure

The procedure includes the following steps:

  • The first step is the WBC extraction through leukapheresis. A machine draws out blood while simultaneously separating the WBC.

  • Then, the extracted cells are taken to a facility that can help transform them into CAR-T cells. The process takes 3-6 weeks.

  • You may be put on radiation therapy or chemotherapy after leukapheresis and before CAR-T cell infusion. This is important to manage blood cancer while CAR-T cells grow in enough quantity to treat your condition.

  • During infusion, you’ll receive lymphodepleting chemotherapy, which reduces the chances of CAR-T cell rejection.

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Benefits and Risk

Benefits

  • Effectively eliminates cancer by specifically targetting those cells

  • Lowest risk of allergic reaction due to the use of patient’s T cells

  • Benefits last for many years (with proper monitoring and recovery) as the living drug can attack cancer cells even if there is a relapse.

  • Successful even in the most aggressive cases of blood cancer

Proper monitoring is essential in cases when you want to establish complete remission and proper effects of the therapy.

 

Risks

 

As with any major treatment, you can expect to experience the following risks:

  • There may be mild neurological issues such as confusion, seizures, difficulty understanding and/or speaking, loss of balance, and hallucinations.

  • Cytokine release syndrome, which is an expected reaction that occurs when large amounts of cytokines, which are the signalling molecules, are released.

  • Weakened immune system, which can increase the risk of infections.

  • Risk of secondary cancers such as T-cell lymphomas

  • Blood disorders such as low platelet count, anemia, allergic reactions

If you experience any of these symptoms, it is best to inform your doctor and medical team. Be sure to consult with them before making any treatment decisions.

Recovery

Ensuring proper recovery is key to prolonging the positive effects of this therapy. Here are a few ways you can get it right:

  • Adhering to the recovery plan recommended by your doctor. For example, staying at the hospital for 7-10 days.

  • Having a caregiver at all times till at least 1-1.5 months after the therapy. This helps with proper monitoring.

  • Maintaining a proper diet as recommended by the doctor.

  • Showing up for every follow-up appointment is helpful in keeping an eye on the remission.

Stay in touch with your doctor and medical team for complete monitoring. This will also help you avoid severe reactions.

Why choose Yapita Health for CAR T-cell Therapy

As a companion in your medical journey, we ensure you get the best on-ground support apart from world-class CAR-T cell therapy at the top hospitals in India.

Get in touch with us today to improve your health outcomes!

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